Garfield, the fat, lazy, lasagna-loving, Monday-hating feline, has everything a cat could want. But when his human, Jon Arbuckle (Breckin Meyer), in an effort to impress veterinarian and old high-school crush Liz, adopts a dog named Odie and brings him home, Garfield gets the one thing he doesn't want: competition. One night, Odie runs away and gets abducted after Garfield locks him outside. In an out-of-character move, Garfield goes to search for and rescue him with help from a variety of animal friends.