Blending traditional folk beliefs with modern fantasy, Agent from Above follows Han Chieh, a spirit medium bound to serve the Third Crown Prince to atone for a childhood mistake by resolving supernatural disturbances in the human world. Along the way, he meets the optimistic college student Yeh Tzu and detective Chang Min, who can see spirits. Together, they face deadly confrontations with the mysterious and ruthless villain Chen Chi-sha, while uncovering the truth behind Wu Tien-chi, a being threatening the balance between the human and demon realms leading Han Chieh to rediscover his purpose and the true meaning of his gift.