Lowly, inept hitman Larry Gigli is assigned a job by the mob to kidnap the intellectually-disabled brother of a California district attorney. Gigli abducts the brother from his mental hospital and holds him hostage in his apartment. Ricki, a "lesbian assassin," is sent to oversee Gigli's job and make sure he doesn't screw it up. Comedic hijinks ensue as the two go on the lam and start to fall in love.