Shy, introverted Karian Edwards looks forward to a weekend at her aunt's house in the desert with her best friend, Cloudy, and their friend, Jessica. Things take a turn for the worse when Cloudy invites along a childhood friend, Sasha Mills, a down-and-out actress who is trying to escape her problems with drugs and alcohol. The four girls take datura, a powerful psychotropic drug, and things quickly turn into a nightmare as the lines between reality and hallucination blur.