Audrey (Mila Kunis) and Morgan (Kate McKinnon), two 30-year-old best friends in Los Angeles, are thrust unexpectedly into an international conspiracy when Audrey's ex-boyfriend shows up at their apartment with a team of deadly assassins on his trail. Surprising even themselves, the duo jump into action, on the run throughout Europe from assassins and a suspicious-but-charming British agent as they hatch a plan to save the world.